Is target protection a mechanism of antibiotic resistance?

Target protection was first recognized as a mechanism of antibiotic resistance in the context of tetracycline resistance ∼ 30 years ago 5, 6, and for some considerable time thereafter this remained the only clearly documented example.

What mechanisms promote or enable drug resistance?

This paper outlines the current knowledge of mechanisms that promote or enable drug resistance, such as drug inactivation, drug target alteration, drug efflux, DNA damage repair, cell death inhibition, and the epithelial-mesenchymal transition, as well as how inherent tumor cell heterogeneity plays a role in drug resistance.

What if a species has intrinsic resistance to a drug?

If that average MIC for a species is in the resistant part of the range, the species is considered to have intrinsic resistance to that drug. Bacteria may also acquire resistance genes from other related organisms, and the level of resistance will vary depending on the species and the genes acquired ,. 3.1. Natural resistance

Why do antibiotic strains have multiple drug resistance?

Because resistance traits are not necessarily eliminated or reversed, resistance to a variety of antibiotics may be accumulated over time. This can lead to strains with multiple drug resistance, which are more difficult to eliminate due to limited effective treatment options.